What can tell an epigenetic driver from noise? The key is proteomics! Dive into our Pan-Cancer methylation paper, just released in Cancer Cell. We have leveraged the power of the CPTAC multiomic dataset to identify aberrant DNA methylation with concurrent transcriptional and translational changes across 7 cancer types. We have pinpointed the lineage-specific epigenetic drivers and methylation subtypes, illuminating how DNA methylation affects cancer genes and tumor phenotypes. Shout out to the methylation team! Enjoy the paper here